Evidence-based clinical practice guidelines for the management of osteoarthritis in adults who are obese or overweight demonstrates interventions including physical activity and diet produces the most beneficial results.

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Weight loss has been identified as one of the main interventions that will improve osteoarthritis of the weight bearing joints. Research comparing obese/non-obese individuals demonstrated a 13-fold increase in the incidence of knee osteoarthritis (OA) among the heaviest subjects.

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Research demonstrates that studies describing overweight people with radiological evidence of knee (OA) who, upon losing 10 to 12 pounds on average, reported a 30%improvement in knee pain and experienced 24% improvement in their ability to perform daily activities.